Gold Nanorod-Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo

被引：680

作者：

Jang, Boseung ^{[1
]}

Park, Jin-Young ^{[1
]}

Tung, Ching-Hsuan ^{[2
]}

Kim, In-Hoo ^{[1
]}

Choi, Yongdoo ^{[1
]}

机构：

[1] Natl Canc Ctr, Mol Imaging & Therapy Branch, Goyang 410769, Gyeonggi Do, South Korea

[2] Cornell Univ, Dept Radiol, Methodist Hosp Res Inst, Weill Med Coll, Houston, TX 77030 USA

来源：

ACS NANO | 2011年 / 5卷 / 02期

关键词：

photodynamic therapy; gold nanorod; NIR fluorescence imaging; photothermal therapy; in vivo; PHOTODYNAMIC THERAPY; SINGLET OXYGEN; SIZE; PHTHALOCYANINE; NANOPARTICLES; PRINCIPLES; EFFICACY; GROWTH; CELLS; MICE;

D O I：

10.1021/nn102722z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A gold nanorod (GNR)-photosensitizer complex was developed for noninvasive near-infrared fluorescence imaging and cancer therapy. We showed that (a) fluorescence emission and singlet oxygen generation by AIPcS4 were quenched after complex formation with GNRs; (b) 4-fold greater intracellular uptake and better in vitro phototoxicity were observed in GNR-AIPcS(4)-treated cells than in free AIPcS(4)-treated cells; and (c) after intravenous injection of the GNR-AIPcS(4) complex, tumor sites were clearly identified on near-Infrared fluorescence images as early as 1 h after injection. The tumor-to-background ratio increased over time and was 33 at 24 h; tumor growth reduced by 79% with photodynamic therapy (PDT) alone and by 95% with dual photothermal therapy (PTT) and PDT. This novel multifunctional nanomedicine may be useful for near-infrared fluorescence imaging and PTT/PDT in various cancers.

引用

页码：1086 / 1094

页数：9

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