HMG-1 rediscovered as a cytokine

被引：156

作者：

Yang, H ^{[1
]}

Wang, HC ^{[1
]}

Tracey, KJ ^{[1
]}

机构：

[1] N Shore Univ Hosp, Lab Biomed Sci, Manhasset, NY 11030 USA

来源：

SHOCK | 2001年 / 15卷 / 04期

关键词：

high mobility group-1; cytokine; tumor necrosis factor; inflammation; sepsis; shock; lipopolysaccharide; endotoxemia;

D O I：

10.1097/00024382-200115040-00001

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

High-mobility group-1 (HMG-1), an abundant, highly conserved cellular protein, is widely known as a nuclear DNA-binding protein that stabilizes nucleosome formation, facilitates gene transcription, and regulates the activity of steroid hormone receptors. We discovered that HMG-1 is a late mediator of delayed endotoxin lethality. When released by activated monocytes, it participates in the development of lethality and it activates downstream cytokine release. This review covers the general features of HMG-1 and its newly appreciated role as a cytokine.

引用

页码：247 / 253

页数：7

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