The therapeutic potential of oral creatine supplementation in muscle disease

被引：22

作者：

Wyss, M

Felber, S

Skladal, D

Koller, A

Kremser, C

Sperl, W

机构：

[1] Univ Innsbruck, Dept Transplant Surg, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Dept Magnet Resonance Imaging, A-6020 Innsbruck, Austria

[3] Univ Innsbruck, Dept Pediat, A-6020 Innsbruck, Austria

[4] Univ Innsbruck, Dept Sports Med, A-6020 Innsbruck, Austria

[5] LKA Salzburg, Childrens Hosp, Salzburg, Austria

来源：

MEDICAL HYPOTHESES | 1998年 / 51卷 / 04期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S0306-9877(98)90058-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The decrease in intracellular creatine concentration observed in a number of muscle diseases may deplete energy homeostasis and may, therefore, be one of the factors determining and/or aggravating muscle weakness and degeneration. Two hypotheses are put forward in the present communication to explain: (i) the mechanisms leading to the disturbances in creatine metabolism found in various muscle diseases; and (ii) the potential of oral creatine supplementation in alleviating the clinical symptoms.

引用

页码：333 / 336

页数：4

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