Cell cycle progression without cyclin E/CDK2: Breaking down the walls of dogma

被引：64

作者：

Gladden, AB ^{[1
]}

Diehl, JA ^{[1
]}

机构：

[1] Univ Penn, Abramson Family Canc Ctr, Dept Canc Biol, Leonard & Madlyn Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

来源：

CANCER CELL | 2003年 / 4卷 / 03期

关键词：

D O I：

10.1016/S1535-6108(03)00217-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

G1 is the phase of the cell cycle wherein the cell is responsive to growth factor-dependent signals. As such, G1 regulation is frequently disrupted in cancer through deregulation of cyclin/CDK activity; deregulation of G1 phase provides tumorigenic cells with a growth advantage. Cyclin E, the regulatory cyclin for CDK2, is considered a requisite regulator of G1 progression. Cyclin E is overexpressed in cancer, suggesting that cyclin E/CDK2 deregulation contributes to tumorigenesis. Two papers now challenge both the concept that cyclin E/CDK2 is a requisite component of the cell cycle machine and efforts to develop cyclin E/CDK2 inhibitors as anti proliferative therapeutics.

引用

页码：160 / 162

页数：3