A drug dosage table is a useful tool to facilitate prescriptions of antiretroviral drugs for children in Thailand

被引:13
作者
Ponnet, M
Frederix, K
Petdachai, W
Wilson, D
Eksaengsri, A
Zachariah, R
机构
[1] Med Sans Frontieres, Brussels Operat Ctr, Dept Med, L-1617 Gasperich, Luxembourg
[2] Prachomklao Hosp, Dept Paediat, Petchburi, Belgium
[3] Govt Pharmaceut Org, Tech & Informat Unit, R&D Inst, Bangkok, Thailand
[4] Med Sans Frontieres, Operat Res, Dept Med, L-1617 Gasperich, Luxembourg
关键词
HAART; drug dosages; paediatric formulations; Thailand;
D O I
10.1258/0956462054094114
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Scaling up of antiretroviral treatment (ART) for children in countries like Thailand will require decentralization and management by non-specialist doctors. We describe (a) the formulation of a standardized drug dosage table to facilitate antiretroviral drug (ARV) prescriptions for children, (b) the acceptability of such a table among doctors and (c) the safety and efficacy of drug doses in the table. Acceptability was assessed using a questionnaire. Safety and efficacy were assessed on the basis of incidence of adverse effects and virological response to treatment, respectively. Of all doctors (n = 18), 17 (94%) found that the table was practical to use, avoided miscalculations and made them more confident with prescriptions. Of 49 children prescribed ARVs, less than 5% had adverse side-effects. All ARV-naive children achieved undetectable viral loads within six months of ART. In our setting, a standardized drug dosage table provided a simple and reliable tool that facilitated ARV prescriptions for children.
引用
收藏
页码:420 / 426
页数:7
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