Serum levels of apoptosis biomarkers, survivin and TNF-alpha in nonsmall cell lung cancer

被引：65

作者：

Derin, Duygu ^{[1
]}

Soydinc, Hilat Oguz ^{[1
]}

Guney, Nese ^{[1
]}

Tas, Faruk ^{[1
]}

Camlica, Hakan ^{[1
]}

Duranyildiz, Derya ^{[1
]}

Yasasever, Vildan ^{[1
]}

Topuz, Erkan ^{[1
]}

机构：

[1] Istanbul Univ, Inst Oncol, Istanbul, Turkey

来源：

LUNG CANCER | 2008年 / 59卷 / 02期

关键词：

survivin; TNF-alpha; apoptosis; nonsmall cell lung cancer; TUMOR-NECROSIS-FACTOR; PROGNOSTIC-FACTOR; PROINFLAMMATORY CYTOKINES; COLORECTAL-CARCINOMA; GENE-EXPRESSION; MESSENGER-RNA; PHASE-II; INTERFERON; STAGE; CHEMOTHERAPY;

D O I：

10.1016/j.lungcan.2007.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Context: This study was conducted to investigate the prognostic role and the effects of chemotherapy on serum apoptosis biomarkers consisting of survivin and tumor necrosis factor alpha (TNF-alpha) in patients with advanced stage nonsmall cell lung cancer (NSCLC). Materials and methods: Fifty-seven patients with newly diagnosed NSCLC were enrolled into study. Performance status was 0 or 1 in 47 patients and 2 in 10 patients. Thirty-two of them were no or less than 10% weight toss. Patients were treated with platinum-based chemotherapy. Serum levels of TNF-atpha and survivin were determined by enzyme-linked immunosorbent assay (ELISA) technique. Results: White serum survivin levels in patients were not significantly different from controls (p = 0.321), serum TNF-alpha levels in patients were found significantly higher than in controls (p = 0.029). We found that serum TNF-alpha levels were increased (p < 0.001), whereas serum levels of survivin (p = 0.025) were decreased by the chemotherapy effects. The changes of the TNF-alpha and survivin serum levels due to chemotherapy effect showed a significant negative correlation (r = -0.36 p = 0.007). The increase of serum TNF-alpha levels was independent from chemotherapy response; however, the reduction of serum survivin levels was found only significant in the chemoresponsive group (p=0.039). White older age, weight loss and performance status yielded prognostic value, neither TNF-alpha nor survivin levels proved to be significant for survival. Conclusion: Our findings suggest that the reduction in the serum survivin levels of advanced NSCLC patients after chemotherapy can be used as a predictor of response to the chemotherapy but not that of survival. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：240 / 245

页数：6

共 42 条

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