Influence of contractile agonists on the mechanism of endothelium-dependent relaxation in rat isolated mesenteric artery

被引：50

作者：

Plane, F

Garland, CJ

机构：

[1] Department of Pharmacology, University of Bristol, Bristol, BS8 1TD, University Walk

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1996年 / 119卷 / 02期

基金：

英国惠康基金;

关键词：

nitric oxide; endothelium-dependent hyperpolarization; vascular smooth muscle;

D O I：

10.1111/j.1476-5381.1996.tb15970.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase-independent repolarization to acetylcholine-evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre-contraction. Noradrenaline-induced contractions were reversed by acetylcholine via both NO and NO synthase-independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane-mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential.

引用

页码：191 / 193

页数：3

共 5 条

[1] Evidence for mediation by endothelium-derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage-operated Ca2+ channels [J].