Sex hormones and the immune response in humans

被引：817

作者：

Bouman, A

Heineman, MJ

Faas, MM

机构：

[1] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, Div Med Biol, NL-9713 GZ Groningen, Netherlands

[2] Univ Groningen, Med Ctr, Dept Obstet & Gynaecol, NL-9713 GZ Groningen, Netherlands

来源：

HUMAN REPRODUCTION UPDATE | 2005年 / 11卷 / 04期

关键词：

cytokines; immune response; leukocytes; reproductive condition sex hormones;

D O I：

10.1093/humupd/dmi008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In addition to their effects on sexual differentiation and reproduction, sex hormones appear to influence the immune system. This results in a sexual dimorphism in the immune response in humans: for instance, females produce more vigorous cellular and more vigorous humoral immune reactions, are more resistant to certain infections, and suffer a higher incidence of autoimmune diseases. Disease expression is also affected by the reproductive status of the female. As sex steroids-estrogens, progesterone and testosterone-differ between gender and within different reproductive stages, a lot of research has focussed on the effects of sex hormones on immune responses. Although there is also a vast literature on the effects of sex hormones on immune responses in animals, in this review we will focus on the most intriguing effects and mechanisms by which sex hormones affect different components of the immune system in humans.

引用

页码：411 / 423

页数：13

共 183 条

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