Model complexes of the active site in peptide deformylase:: A new family of mononuclear N2S-M(II) complexes

被引：33

作者：

Chang, SC ^{[1
]}

Karambelkar, VV ^{[1
]}

diTargiani, RC ^{[1
]}

Goldberg, DP ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

INORGANIC CHEMISTRY | 2001年 / 40卷 / 02期

关键词：

D O I：

10.1021/ic001079b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new tridentate N2Sthiolate ligand, PATH, has been prepared and includes a sterically hindered aliphatic thiolate donor as a cysteine mimic. PATH was employed in the synthesis of the monomeric complexes [(PATH)(MBr)-Br-[]] and [(PATH)(MNCS)-N-[]] (M = Zn, Co), which have been characterized by X-ray diffraction. These complexes are close structural analogues of the His(2)Cys site found in peptide deformylase.

引用

页码：194 / +

页数：3

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