Tolerance of efavirenz in children

Objective: To extend the limited knowledge of efavirenz tolerance in children. Method: An observational study of 33 children given efavirenz combined with various others agents and followed in a single institution. Results: Fifteen (42%) of the children presented at least one clinically discernable side effect, cutaneous (n = 5), nervous system (n = 10), or both (n = 2). Intolerance led to treatment interruption in seven children but the main symptom was transitory dizziness or other signs similar to those observed in adults. Conclusion: Early, often transient nervous system side effects require careful preparation with the child and his family to avoid premature and inadequate withdrawal from treatment. (C) 2001 Lippincott Williams & Wilkins.