Raman spectral mapping in the assessment of axillary lymph nodes in breast cancer

被引：53

作者：

Smith, J

Kendall, C

Sammon, A

Christie-Brown, J

Stone, N

机构：

[1] Gloucestershire Royal Hosp, Breast Surg Unit, Gloucester GL1 3NN, England

[2] Gloucestershire Royal Hosp, Cranfield Postgrad Med Sch, Gloucester GL1 3NN, England

[3] Gloucestershire Royal Hosp, Dept Histopathol, Gloucester GL1 3NN, England

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2003年 / 2卷 / 04期

关键词：

Raman spectroscopy; breast cancer; axillary lymph nodes;

D O I：

10.1177/153303460300200407

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This paper is the first reported description of Raman Spectroscopy in the assessment of axillary lymph nodes in breast cancer patients. Raman Spectroscopy is an inelastic scattering spectroscopic technique appropriate for the assessment of unprocessed complex biological tissues. Spectra represent biochemical signatures of the tissue under scrutiny. The described method of Raman spectral mapping produces false-color spectral images of lymph node sections. These can be compared with standard histopathology slides and white light images of nodal tissue. This method has the potential to allow the detailed biochemical assessment of heterogeneous lymph node features, and to contribute towards the development of an optical diagnostic tool for use in a clinical setting.

引用

页码：327 / 331

页数：5

共 14 条

[1]

BRIGGS GM, 2002, EUROPEAN J SURG ONCO, V28, P771

[2]

CHATTERJEE SJ, 2002, MULTIDISCIPLINARY AP, P69

[3]

CONTRACTOR K, 2002, EUROPEAN J SURG ONCO, V28, P787

[4] PROGNOSTIC-SIGNIFICANCE OF BREAST-CANCER AXILLARY LYMPH-NODE MICROMETASTASES ASSESSED BY 2 SPECIAL TECHNIQUES - REEVALUATION WITH LONGER FOLLOW-UP [J].