Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers

被引：80

作者：

Liu, L ^{[1
]}

Li, CX ^{[1
]}

Li, XC ^{[1
]}

Yuan, Z ^{[1
]}

An, YL ^{[1
]}

He, BL ^{[1
]}

机构：

[1] Nankai Univ, Inst Polymer Chem, State Key Lab Funct Polymer Mat Adsorpt & Separat, Tianjin 300071, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2001年 / 80卷 / 11期

关键词：

biodegradable; polylactide; poly(ethylene glycol); micelles; drug delivery;

D O I：

10.1002/app.1295

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Adriamycin (ADR) was selected as a model drug to evaluate the potential applications of polylactide/poly(ethylene glycol)/polylactide (PLA/PEG/PLA) micelles as drug carriers in parenteral delivery systems. The PLA/PEG/PLA triblock copolymer micelles were characterized by dynamic light scattering and transmission electron microscopy. It was found that the micelle size increased with the increasing of the PLA chain length. The average size of ADR-loaded micelles was 143.2 nm. The histogram analysis showed that the ADR-loaded micelles possessed a narrow unimodal size distribution. The ADR loading contents of the micelles and ADR entrapment efficiency were dependent on the PLA chain length and PEG chain length in the copolymer. They increased with the increase of the PLA chain length, but the PEG chain length was identical and decreased with the increase of the PEG chain length; the length of the PLA block was similar. The initial amount of ADR also influenced the drug contents and entrapment efficiency (i.e., the more the initial amount added, the more the drug contents and the higher encapsulation efficiency). The drug release experiments indicated that the ADR-loaded micelles possessed sustained release characteristics. (C) 2001 John Wiley & Sons, Inc.

引用

页码：1976 / 1982

页数：7

共 20 条

[1] MICELLE FORMATION OF BAB TRIBLOCK COPOLYMERS IN SOLVENTS THAT PREFERENTIALLY DISSOLVE THE A-BLOCK [J].