Activation of metabotropic glutamate receptors induces gamma frequency oscillations in the rat dentate gyrus in vivo

被引：12

作者：

Martin, SJ ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Neurosci, Edinburgh EH8 9LE, Midlothian, Scotland

来源：

NEUROPHARMACOLOGY | 2001年 / 40卷 / 04期

关键词：

gamma oscillations; mGluR; ACPD; MCPG; hippocampus; dentate gyrus;

D O I：

10.1016/S0028-3908(00)00190-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activation of mGluRs has previously been reported to cause beta/gamma frequency oscillations in CA1 hippocampal slices. The present study reveals that pharmacological activation of mGluRs in vivo induces dentate EEG oscillations at the low end of the gamma frequency range, with peak activity just below 30 Hz. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：634 / 637

页数：4

共 10 条

[1]

BODDEKE HWG, 1997, NEUROSCIENCE, V76, P635

[2]

BRAGIN A, 1995, J NEUROSCI, V15, P47

[3] Coincident activation of mGluRs and mAChRs imposes theta frequency patterning on synchronised network activity in the hippocampal CA3 region [J].

Cobb, SR ;

Bulters, DO ;

Davies, CH .

NEUROPHARMACOLOGY, 2000, 39 (11) :1933-1942

[4] OSCILLATORY RESPONSES IN CAT VISUAL-CORTEX EXHIBIT INTER-COLUMNAR SYNCHRONIZATION WHICH REFLECTS GLOBAL STIMULUS PROPERTIES [J].

GRAY, CM ;

KONIG, P ;

ENGEL, AK ;

SINGER, W .

NATURE, 1989, 338 (6213) :334-337

[5] CARBACHOL-INDUCED EEG THETA-ACTIVITY IN HIPPOCAMPAL BRAIN-SLICES [J].

KONOPACKI, J ;

MACIVER, MB ;

BLAND, BH ;

ROTH, SH .

BRAIN RESEARCH, 1987, 405 (01) :196-198

[6] (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo [J].

Martin, SJ ;

Morris, RGM .

NEUROPHARMACOLOGY, 1997, 36 (10) :1339-1354

[7] AN ANALYSIS OF CHOLINOCEPTIVE NEURONS IN THE HIPPOCAMPAL-FORMATION BY DIRECT MICROINFUSION [J].

ROWNTREE, CI ;

BLAND, BH .

BRAIN RESEARCH, 1986, 362 (01) :98-113

[8]

Taylor RT, 1995, BIOREMED SER, V3, P15

[9]

TRAUB RD, 1999, FAST OSCILLATIONS CO, P237

[10] SYNCHRONIZED OSCILLATIONS IN INTERNEURON NETWORKS DRIVEN BY METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION [J].

WHITTINGTON, MA ;

TRAUB, RD ;

JEFFERYS, JGR .

NATURE, 1995, 373 (6515) :612-615

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