GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells

被引：262

作者：

Cossart, R ^{[1
]}

Esclapez, M ^{[1
]}

Hirsch, JC ^{[1
]}

Bernard, C ^{[1
]}

Ben-Ari, Y ^{[1
]}

机构：

[1] Hop Port Royal, INSERM, U29, F-75014 Paris, France

来源：

NATURE NEUROSCIENCE | 1998年 / 1卷 / 06期

关键词：

D O I：

10.1038/2185

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the modulation of GABAergic inhibition by glutamate and kainate acting on GluR5-containing kainate receptors in the CA1 hippocampal region. Glutamate, kainate or ATPA, a selective agonist of GluR5-containing receptors, generates an inward current in inhibitory interneurons and cause repetitive action potential firing. This results in a massive increase of tonic GABAergic inhibition in the somata and apical dendrites of pyramidal neurons. These effects are prevented by the GluR5 antagonist LY 293558. Electrical stimulation of excitatory afferents generates kainate receptor-mediated excitatory postsynaptic currents (EPSCs) and action potentials in identified interneurons that project to the dendrites and somata of pyramidal neurons. Therefore glutamate acting on kainate receptors containing the GluR5 subunit may provide a protective mechanism against hyperexcitability.

引用

页码：470 / 478

页数：9

共 39 条

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