FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

被引：897

作者：

Welcker, Markus ^{[2
]}

Clurman, Bruce E. ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Med, Sch Med, Seattle, WA 98104 USA

[2] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[3] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 02期

关键词：

D O I：

10.1038/nrc2290

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)type ubiquitin ligase. SCFFBW7 degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies. Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis. This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer.

引用

页码：83 / 93

页数：11

共 119 条

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