Coronary arterial calcification: A review of mechanisms, promoters and imaging

被引：93

作者：

Andrews, Jordan ^{[1
,2
,3
]}

Psaltis, Peter J. ^{[1
,2
,3
]}

Di Bartolo, Belinda A. ^{[1
,2
,3
]}

Nicholls, Stephen J. ^{[1
,2
,3
]}

Puri, Rishi ^{[3
,4
,5
]}

机构：

[1] Univ Adelaide, Vasc Res Ctr, Heart Hlth Theme, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[2] Univ Adelaide, Sch Med, Adelaide, SA, Australia

[3] Univ Adelaide, Dept Med, Adelaide, SA, Australia

[4] Cleveland Clin, Dept Cardiovasc Med, 9500 Euclid Ave,Mail Code J2-208m, Cleveland, OH 44195 USA

[5] Cleveland Clin, C5R, Cleveland, OH 44106 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2018年 / 28卷 / 08期

关键词：

Calcium; Plaque; IVUS; CTCA; Calcium scoring; MATRIX GLA PROTEIN; ACUTE MYOCARDIAL-INFARCTION; CALCIUM/VITAMIN-D SUPPLEMENTATION; 18F-SODIUM FLUORIDE UPTAKE; LIPID-LOWERING THERAPY; VASCULAR SMOOTH-MUSCLE; INTRAVASCULAR ULTRASOUND; SPOTTY CALCIFICATION; PLAQUE COMPOSITION; OXIDATIVE STRESS;

D O I：

10.1016/j.tcm.2018.04.007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Coronary artery calcification (CAC) was once thought to be a passive, degenerative, and quiescent development of disease. However, it has now been shown to be an active process associated with atherosclerosis that is stimulated by inflammatory pathways. Calcification forms within the intimal and medial layers of the vessel wall by way of mechanisms similar to bone development. A variety of imaging modalities have been used to identify and characterize CAC, from early microcalcifications to well-developed fibroatheromas that have calcified. There are sex and race differences in prevalence and development of CAC, and medical therapies such as statin and warfarin use exhibit pro-calcific effects on the vessel wall. Effective medical treatment of CAC has yet to be established; therefore a greater understanding of the factors that induce calcification is needed to develop appropriate therapeutic strategies. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：491 / 501

页数：11

共 111 条

[1]

Vascular calcification - Mechanisms and clinical ramifications [J].