Derailing the Wacker oxidation: Development of a palladium-catalyzed amidation reaction

被引：91

作者：

Gaunt, MJ ^{[1
]}

Spencer, JB ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 01期

关键词：

D O I：

10.1021/ol0066882

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A conceptually new palladium-catalyzed amidation reaction is described for the synthesis of beta -amido ketones based on derailing the Wacker oxidation of enones. This reaction generates a new carbon-nitrogen bond via a palladium-catalyzed conjugate addition of a carbamate nucleophile to an enone, The regiocontrol, mild and neutral conditions, lack of preactivation of the nucleophile, and lack of reoxidation system for the catalyst are attractive features of this transformation.

引用

页码：25 / 28

页数：4

共 28 条

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