The inhibitor of apoptosis proteins as therapeutic targets in cancer

被引:163
作者
Vucic, Domagoj [1 ]
Fairbrother, Wayne J. [1 ]
机构
[1] Genentech Inc, Dept Prot Engn, San Francisco, CA 94080 USA
关键词
D O I
10.1158/1078-0432.CCR-07-0729
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Apoptosis is a cell suicide process with a major role in development and homeostasis in vertebrates and invertebrates. Inhibition of apoptosis enhances the survival of cancer cells and facilitates their escape from immune surveillance and cytotoxic therapies. Among the principal molecules contributing to this phenomenon are the inhibitor of apoptosis (IAP) proteins, a family of antiapoptotic regulators that block cell death in response to diverse stimuli through interactions with inducers and effectors of apoptosis. IAP proteins are expressed in the majority of human malignancies at elevated levels and play an active role in promoting tumor maintenance through the inhibition of cellular death and participation in signaling pathways associated with malignancies. Here, we discuss the role of IAP proteins in cancer and options for targeting IAP proteins for therapeutic intervention.
引用
收藏
页码:5995 / 6000
页数:6
相关论文
共 88 条
[1]   The case for survivin as a regulator of microtubule dynamics and cell-death decisions [J].
Altieri, Dario C. .
CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (06) :609-615
[2]   Validating survivin as a cancer therapeutic target [J].
Altieri, DC .
NATURE REVIEWS CANCER, 2003, 3 (01) :46-54
[3]   Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ [J].
Arnt, CR ;
Chiorean, MV ;
Heldebrant, MV ;
Gores, GJ ;
Kaufmann, SH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (46) :44236-44243
[4]   Apoptosis control by death and decoy receptors [J].
Ashkenazi, A ;
Dixit, VM .
CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) :255-260
[5]  
Asselin E, 2001, CANCER RES, V61, P1862
[6]   Biochemical pathways of caspase activation during apoptosis [J].
Budihardjo, I ;
Oliver, H ;
Lutter, M ;
Luo, X ;
Wang, XD .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :269-290
[7]   XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer [J].
Cao, C ;
Mu, Y ;
Hallahan, DE ;
Lu, B .
ONCOGENE, 2004, 23 (42) :7047-7052
[8]   Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis [J].
Carter, BZ ;
Kornblau, SM ;
Tsao, T ;
Wang, RY ;
Schober, WD ;
Milella, M ;
Sung, HG ;
Reed, JC ;
Andreeff, M .
BLOOD, 2003, 102 (12) :4179-4186
[9]   Structural and biochemical basis of apoptotic activation by Smac/DIABLO [J].
Chai, JJ ;
Du, CY ;
Wu, JW ;
Kyin, S ;
Wang, XD ;
Shi, YG .
NATURE, 2000, 406 (6798) :855-862
[10]   Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM) [J].
Chauhan, Dharminder ;
Neri, Paola ;
Velankar, Mugdha ;
Podar, Klaus ;
Hideshima, Teru ;
Fulciniti, Mariateresa ;
Tassone, Pierfrancesco ;
Raje, Noopur ;
Mitsiades, Constantine ;
Mitsiades, Nicholas ;
Richardson, Paul ;
Zawel, Leigh ;
Tran, Mary ;
Munshi, Nikhil ;
Anderson, Kenneth C. .
BLOOD, 2007, 109 (03) :1220-1227