Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets

被引：5

作者：

Efanov, AM

Zaitsev, SV

Berggren, PO

Mest, HJ

Efendic, S ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Hosp, Dept Mol Med, Rolf Luft Ctr Diabet Res, S-17176 Stockholm, Sweden

[2] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119899, Russia

[3] Lilly Forsch GMBH, Lilly Res Labs, Dept Pharmacol, D-22419 Hamburg, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 281卷 / 05期

关键词：

imidazoline; insulin secretion; DAG; pancreatic islets;

D O I：

10.1006/bbrc.2001.4483

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Imidazoline compound RX871024 and carbamylcholine (CCh) stimulate insulin secretion in isolated rat pancreatic islets. Combination of CCh and RX871024 induces a synergetic effect on insulin secretion. RXS71024 and CCh produce twofold increases in diacylglycerol (DAG) concentration. The combination of two compounds has an additive effect on DAG concentration. Effects of RX871024 on insulin secretion and DAG concentration are not dependent on the presence of D609, an inhibitor of pho sphatidylcholine-specific phospholipase C. It is concluded that as in case with CCh the increase in DAG concentration induced by imidazoline RX871024 contributes to the insulinotropic activity of the compound, (C) 2001 Academic Press.

引用

页码：1070 / 1073

页数：4

共 21 条

[1]

ARKHAMMAR P, 1994, J BIOL CHEM, V269, P2743

[2] Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release [J].