Genetic mapping and embryonic expression of a novel, maternally transcribed gene Mem3

被引：21

作者：

Hwang, SY

Benjamin, LE

Oh, B

Rothstein, JL

Ackerman, SL

Beddington, RSP

Solter, D

Knowles, BB

机构：

[1] JACKSON LAB,BAR HARBOR,ME 04609

[2] MAX PLANCK INST IMMUNOBIOL,D-79108 FREIBURG,GERMANY

[3] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,IL-91120 JERUSALEM,ISRAEL

[4] THOMAS JEFFERSON UNIV,SCH MED,PHILADELPHIA,PA 19104

[5] NATL INST MED RES,MRC,LONDON NW7 1AA,ENGLAND

来源：

MAMMALIAN GENOME | 1996年 / 7卷 / 08期

关键词：

D O I：

10.1007/s003359900174

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To study the molecular function of genes expressed during preimplantation development, we isolated a novel maternal transcript SSEC (Stage Specific Embryonic cDNA)-26 from a par tial subtraction library of mouse unfertilized eggs and preimplantation embryos. The SSEC-26 transcript is abundant in the unfertilized egg and also actively transcribed from the newly formed zygotic genome. On the basis of its expression in eggs and embryos, this new mouse gene is named Mem (maternal-embryonic) 3. The genomic locus of Mem3 has been mapped to Chromosome (Chr) 8 near the D8Mit78 marker and the glutaryl CoA dehydrogenase (Gcdh) locus. The deduced amino acid sequence of MEM3 resembles that of the yeast VPS (Vacuolar Protein Sorting) 35 in two separate domains. A cDNA sequence of the potential human homolog of Mem3 has been assembled with partial clones from the EST database and assigned to human Chr 16.

引用

页码：586 / 590

页数：5

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