How do cytotoxic lymphocytes kill their targets?

被引：308

作者：

Shresta, S

Pham, CTN

Thomas, DA

Graubert, TA

Ley, TJ ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Bone Marrow Transplantat & Stem Cell Biol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80227-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

引用

页码：581 / 587

页数：7

共 54 条

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