The biosynthesis of pramanicin: intact incorporation of serine and absolute configuration of the antibiotic

被引：13

作者：

Duspara, P ^{[1
]}

Jenkins, SI ^{[1
]}

Hughes, DW ^{[1
]}

Harrison, PHM ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 23期

关键词：

D O I：

10.1039/a807401a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biosynthetic incorporation of isotopically labelled serines into pramanicin 1 in Stagonospora sp. ATCC 74235 shows that L-serine is incorporated as an intact entity with all four bonds to the alpha-carbon retained; thus 1 is assigned the 5S absolute configuration.

引用

页码：2643 / 2644

页数：2

共 15 条

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