A preliminary investigation on the distribution of cannabinoids in man

被引：61

作者：

Gronewold, Antonia ^{[1
]}

Skopp, Gisela ^{[1
]}

机构：

[1] Univ Hosp, Inst Legal Med & Traff Med, D-69115 Heidelberg, Germany

来源：

FORENSIC SCIENCE INTERNATIONAL | 2011年 / 210卷 / 1-3期

关键词：

Cannabinoids; Postmortem; Distribution in man; LC/MS/MS; TETRAHYDROCANNABINOL; PLASMA; METABOLISM; ORGANS; URINE; THC;

D O I：

10.1016/j.forsciint.2011.04.010

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

030101 [法学理论]; 030111 [法律史学]; 100218 [急诊医学];

摘要：

An LC/MS/MS procedure to determine THC along with its major metabolites 11-OH-THC, THC-COOH and its glucuronide as well as the cannabinoids CBD and CBN was applied to 5 post mortem cases to study their distribution into some less commonly studied matrices. Analytes were determined in fluids and tissue homogenates following protein precipitation and liquid-liquid extraction. Gall bladder fluid exhibited maximum concentrations of all analytes except THC, which was detectable in high concentrations in muscle tissue along with CBD. THC was also present in lung specimens, whereas its concentration in liver samples was low or not detectable at all. Liver und kidney specimens contained appreciable amounts of THC-COOglu. Findings from bile support extensive enterohepatic recirculation of the glucuronide. Muscle tissue seems an interesting specimen to detect multiple cannabis use, and brain may serve as an alternative specimen for blood; nevertheless, the present findings should be substantiated by further investigations. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E7 / E11

页数：5

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