Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins

被引：39

作者：

Spitsin, S ^{[1
]}

Hooper, DC ^{[1
]}

Mikheeva, T ^{[1
]}

Koprowski, H ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Immunol & Microbiol, Philadelphia, PA 19107 USA

来源：

MULTIPLE SCLEROSIS | 2001年 / 7卷 / 03期

关键词：

autoimmunity; twins; demyelinating diseases; multiple sclerosis; uric acid; inosine;

D O I：

10.1177/135245850100700305

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Presence of nitrotyrosine in cells surrounding plaques indicates that peroxynitrite may be the cause of brain lesions in multiple sclerosis. Low levels of uric acid, a natural scavenger of peroxynitrite, were demonstrated in blood of patients with multiple sclerosis in comparison with control individuals. These observations were now extended to 132 sets of twins with one sibling affected by multiple sclerosis. In blood of both mono- and dizygotic twins the uric acid levels were lower in the twin with the disease than in the healthy twin.

引用

页码：165 / 166

页数：2

共 7 条

[1] RELATIVE ROLES OF GENETIC AND ENVIRONMENTAL FACTORS IN CONTROL OF SERUM URIC ACID LEVELS IN NORMOURICAEMIC SUBJECTS [J].