Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl E isopeptides

被引：193

作者：

Sohma, Y ^{[1
]}

Sasaki, M ^{[1
]}

Hayashi, Y ^{[1
]}

Kimura, T ^{[1
]}

Kiso, Y ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Ctr Frontier Res Med Sci, Dept Med Chem, Yamashima Ku, Kyoto 6078412, Japan

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 01期

关键词：

D O I：

10.1039/b312129a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient method for the synthesis of difficult sequence-containing peptides has been developed based on the synthesis of O-acyl isopeptides followed by an O-N intramolecular acyl migration reaction, resulting in a remarkable improvement of the yields.

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收藏

页码：124 / 125

页数：2

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