Indiplon: the development of a new hypnotic

被引：35

作者：

Neubauer, DN ^{[1
]}

机构：

[1] Johns Hopkins, Bayvie Med Ctr, Baltimore, MD 21224 USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2005年 / 14卷 / 10期

关键词：

alpha(1); selective; GABA(A) receptors; hypnotic; indiplon; insomnia; modified release; nonbenzodiazepine; sleep disorders;

D O I：

10.1517/13543784.14.10.1269

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Indiplon is a short-acting hypnotic that is currently being developed as a treatment for insomnia by Neurocrine Biosciences and Pfizer, and is expected to be marketed in mid-2006. It is a high-affinity allosteric potentiator of GABA(A) responses that demonstrates preference for cc, subunit-containing GABA(A) receptors. Indiplon will be an addition to the general category of newer-generation hypnotics that now includes zaleplon, zolpidem, zopiclone and eszopidone. Clinical trials were carried out with an immediate-release capsule and a modified-release tablet and demonstrate very positive efficacy and safety profiles. The major challenge will be developing a commercial success in the crowded insomnia treatment marketplace.

引用

页码：1269 / 1276

页数：8

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