The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

被引：74

作者：

Alfarouk, Khalid O. ^{[1
,2
,3
,4
]}

Bashir, Adil H. H. ^{[2
,5
]}

Aljarbou, Ahmed N. ^{[6
,7
]}

Ramadan, AbdelRahman M. ^{[8
]}

Muddathir, Abdel Khalig ^{[2
,9
]}

AlHoufie, Sari T. S. ^{[3
,10
]}

Hifny, Abdelhamid ^{[11
]}

Elhassan, Gamal O. ^{[12
]}

Ibrahim, Muntaser E. ^{[5
]}

Alqahtani, Saad S. ^{[13
]}

AlSharari, Shakir D. ^{[14
,15
]}

Supuran, Claudiu T. ^{[16
]}

Rauch, Cyril ^{[17
]}

Cardone, Rosa Angela ^{[18
]}

Reshkin, Stephan J. ^{[18
]}

Fais, Stefano ^{[19
]}

Harguindey, Salvador ^{[20
]}

机构：

[1] Alfarouk Biomed Res LLC, Tampa, FL 33617 USA

[2] Hala Alfarouk Canc Ctr, Khartoum, Sudan

[3] Al Ghad Int Coll Appl Med Sci, Medina, Saudi Arabia

[4] Amer Biosci Inc, New York, NY 10913 USA

[5] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan

[6] Qassim Univ, Coll Pharm, Buraydah, Saudi Arabia

[7] Al Ghad Int Coll Appl Med Sci, Jeddah, Saudi Arabia

[8] Taibah Univ, Coll Dent, Medina, Saudi Arabia

[9] Univ Khartoum, Dept Pharmacognosy, Fac Pharm, Khartoum, Sudan

[10] Taibah Univ, Fac Appl Med Sci, Dept Clin Lab Sci, Medina, Saudi Arabia

[11] Al Azhar Univ, Cairo, Egypt

[12] Qassim Univ, Unaizah Coll Pharm, Unaizah, Saudi Arabia

[13] Jazan Univ, Coll Pharm, Clin Pharm Dept, Jazan, Saudi Arabia

[14] King Saud Univ, Dept Pharmacol & Toxicol, Coll Pharm, Riyadh, Saudi Arabia

[15] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

[16] Univ Florence, Florence, Italy

[17] Univ Nottingham, Sch Vet Med & Sci, Nottingham, England

[18] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy

[19] Natl Inst Hlth, Dept Oncol & Mol Med, Rome, Italy

[20] Inst Clin Biol & Metab, Vitoria, Spain

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

关键词：

Helicobacter pylori; gastric cancer; pH; inflammation; pharmacology; GROWTH-FACTOR RECEPTOR; PROTON PUMP INHIBITOR; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CYTOSOLIC PHOSPHOLIPASE A(2); UNIDENTIFIED CURVED BACILLI; EPITHELIAL-CELL APOPTOSIS; ACTIVATED PROTEIN-KINASES; BLOOD-GROUP ANTIGENS;

D O I：

10.3389/fonc.2019.00075

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current pharmacological approach to treat and prevent its carcinogenicity.

引用

页数：12

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