From analytic inversion to contemporary IMRT optimization: Radiation therapy planning revisited from a mathematical perspective

被引：10

作者：

Censor, Yair ^{[1
]}

Unkelbach, Jan ^{[2
,3
]}

机构：

[1] Univ Haifa, Dept Math, IL-31905 Haifa, Israel

[2] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS | 2012年 / 28卷 / 02期

关键词：

Radiation therapy treatment planning; Algebraic inverse planning; Inverse problem; IMRT; BEAM ANGLE OPTIMIZATION; ROTATION THERAPY; ARC; DISTRIBUTIONS; PROJECTIONS; ALGORITHMS; TRANSFORM; DELIVERY; CANCER;

D O I：

10.1016/j.ejmp.2011.04.002

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

In this paper we look at the development of radiation therapy treatment planning from a mathematical point of view. Historically, planning for Intensity-Modulated Radiation Therapy (IMRT) has been considered as an inverse problem. We discuss first the two fundamental approaches that have been investigated to solve this inverse problem: Continuous analytic inversion techniques on one hand, and fully-discretized algebraic methods on the other hand. In the second part of the paper, we review another fundamental question which has been subject to debate from the beginning of IMRT until the present day: The rotation therapy approach versus fixed angle IMRT. This builds a bridge from historic work on IMRT planning to contemporary research in the context of Intensity-Modulated Arc Therapy (IMAT). (C) 2011 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

引用

页码：109 / 118

页数：10

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