Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

被引：37

作者：

Peters, Susan ^{[1
,2
]}

Gallo, Valentina ^{[3
]}

Vineis, Paolo ^{[4
]}

Middleton, Lefkos T. ^{[4
]}

Forsgren, Lars ^{[5
]}

Sacerdote, Carlotta ^{[6
,7
]}

Sieri, Sabina ^{[8
]}

Kyrozis, Andreas ^{[9
,10
]}

Chirlaque, Maria-Dolores ^{[11
,12
,13
]}

Zamora-Ros, Raul ^{[14
]}

Hansson, Oskar ^{[15
,16
]}

Petersson, Jesper ^{[17
]}

Katzke, Verena ^{[18
]}

Kuehn, Tilman ^{[18
]}

Mokoroa, Olatz ^{[19
]}

Masala, Giovanna ^{[20
]}

Ardanaz, Eva ^{[12
,21
,22
]}

Panico, Salvatore ^{[23
]}

Bergmann, Manuela M. ^{[24
]}

Key, Timothy J. ^{[25
]}

Weiderpass, Elisabete ^{[26
]}

Ferrari, Pietro ^{[26
]}

Vermeulen, Roel ^{[1
,4
,27
]}

机构：

[1] Univ Utrecht, Inst Risk Assessment Sci, Yalelaan 2, Utrecht 3584 CM, Netherlands

[2] Univ Med Ctr Utrecht, Dept Neurol, Utrecht, Netherlands

[3] Queen Mary Univ London, Ctr Primary Care & Publ Hlth, London, England

[4] Imperial Coll London, Sch Publ Hlth, London, England

[5] Umea Univ, Dept Clin Sci, Neurosci, Umea, Sweden

[6] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[7] Ctr Canc Prevent, Turin, Italy

[8] Ist Nazl Tumori, Epidemiol & Prevent Unit, Fdn Ist Ricovero & Cura Carattere Sci IRCCS, Milan, Italy

[9] Hellenic Hlth Fdn, Athens, Greece

[10] Natl & Kapodistrian Univ Athens, Dept Neurol 1, Athens, Greece

[11] Inst Murciano Invest Biosanit IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[12] Centrode Invest Biomed Red CIBER Epidemiol & Publ, Madrid, Spain

[13] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[14] Bellvitge Biomed Res Inst, Catalan Inst Oncol, Epidemiol Res Program, Unit Nutr & Canc, Barcelona, Spain

[15] Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmo, Sweden

[16] Skane Univ Hosp, Memory Clin, Lund, Sweden

[17] Lund Univ, Skane Univ Hosp, Dept Neurol, Malmo, Sweden

[18] German Canc Res Ctr, Heidelberg, Germany

[19] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[20] Canc Res & Prevent Inst ISPRO, Inst Canc Res Prevent & Clin Network, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[21] Navarra Publ Hlth Inst, Pamplona, Spain

[22] Navarra Inst Hlth Res, Inst Invest Sanit Navarra IdiSNA, Pamplona, Spain

[23] Federico II Univ Naples, Dipartimento Med Clin & Chirurgia, Naples, Italy

[24] German Inst Human Nutr, Potsdam, Germany

[25] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

[26] Int Agcy Res Canc, Lyon, France

[27] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

来源：

MOVEMENT DISORDERS | 2020年 / 35卷 / 07期

基金：

英国医学研究理事会;

关键词：

alcohol; EPIC; epidemiology; Parkinson; prospective cohort; CIGARETTE-SMOKING; METAANALYSIS; ASSOCIATION; CANCER;

D O I：

10.1002/mds.28039

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective To assess the associations between alcohol consumption and PD risk. Methods Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at similar to 50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. (c) 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

引用

页码：1258 / 1263

页数：6

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