CREM: a master-switch governing male germ cell differentiation and apoptosis

被引：71

作者：

Sassone-Corsi, P ^{[1
]}

机构：

[1] ULP, CNRS, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1998年 / 9卷 / 04期

关键词：

cyclic AMP; transcription factors; spermiogenesis; FSH; cell death;

D O I：

10.1006/scdb.1998.0200

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several endocrine and neuronal functions are governed by the cAMP-dependent signalling pathway. In eukaryotes, transcriptional regulation upon stimulation of the adenylyl cyclase signalling pathway is mediated by a family of cAMP-responsive nuclear factors. The CREM gene plays a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. CREM is highly expressed in postmeiotic cells upon a striking developmental switch regulated by the pituitary hormone FSH. CREM-mutant mice generated by homologous recombination reveal that spermatogenesis stops at the first step of spermiogenesis. Late spermatids are completely absent while there is a significant increase in apoptotic germ cells. A series of post-meiotic germ cell-specific genes are not expressed. Mutant male mice completely lack spermatozoa. This phenotype is reminiscent of cases of human infertility.

引用

页码：475 / 482

页数：8

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