NMDA-receptor contribution to spinal nociceptive reflexes: Influence of stimulus parameters and of preparatory surgery

被引:9
作者
Hartell, NA [1 ]
Headley, PM [1 ]
机构
[1] ASTON UNIV,DEPT PHARMACEUT & BIOL SCI,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND
基金
英国医学研究理事会;
关键词
NMDA; ketamine; wind up; spinal cord; surgery; nociceptive reflex;
D O I
10.1016/S0028-3908(96)00029-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The contribution of NMDA receptors to nociceptive reflexes has been assessed both in awake rats and in electrophysiological tests on alpha-chlorarose anaesthetized spinalized rats prepared with different degrees of surgery. Single motor unit activity was recorded in response to alternating noxious mechanical and electrical stimuli applied to one hindpaw, and the results compared with paw pressure withdrawal reflexes in awake rats. There was little contribution by NMDA receptors to nociceptive paw pinch responses either in awake rats or in rats prepared with minimal surgery, but following extensive lumbar surgery the contribution increased significantly to a level similar to that seen in the wind-up component of responses elicited by electrical stimulation. Surgery therefore has effects several segments from the sensory input that it generates. It enhances the NMDA receptor contribution in responses to some but not all types of afferent input. Copyright (C) 1996 Elsevier Science Ltd.
引用
收藏
页码:1567 / 1572
页数:6
相关论文
共 39 条
[1]   THE DISSOCIATIVE ANESTHETICS, KETAMINE AND PHENCYCLIDINE, SELECTIVELY REDUCE EXCITATION OF CENTRAL MAMMALIAN NEURONS BY N-METHYL-ASPARTATE [J].
ANIS, NA ;
BERRY, SC ;
BURTON, NR ;
LODGE, D .
BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (02) :565-575
[2]   5-HYDROXYTRYPTAMINE, SUBSTANCE-P, AND THYROTROPIN-RELEASING-HORMONE IN THE ADULT CAT SPINAL-CORD SEGMENT L7 - IMMUNOHISTOCHEMICAL AND CHEMICAL STUDIES [J].
ARVIDSSON, U ;
CULLHEIM, S ;
ULFHAKE, B ;
BENNETT, GW ;
FONE, KCF ;
CUELLO, AC ;
VERHOFSTAD, AAJ ;
VISSER, TJ ;
HOKFELT, T .
SYNAPSE, 1990, 6 (03) :237-270
[3]   EFFECTS OF N-METHYL-D-ASPARTATE ANTAGONISTS AND SPANTIDE ON SPINAL REFLEXES AND RESPONSES TO SUBSTANCE-P AND CAPSAICIN IN ISOLATED SPINAL-CORD PREPARATIONS FROM MOUSE AND RAT [J].
BRUGGER, F ;
EVANS, RH ;
HAWKINS, NS .
NEUROSCIENCE, 1990, 36 (03) :611-622
[4]   THE BEHAVIORAL-EFFECTS OF AN N-METHYLASPARTATE RECEPTOR ANTAGONIST FOLLOWING APPLICATION TO THE LUMBAR SPINAL-CORD OF CONSCIOUS RATS [J].
CAHUSAC, PMB ;
EVANS, RH ;
HILL, RG ;
RODRIQUEZ, RE ;
SMITH, DAS .
NEUROPHARMACOLOGY, 1984, 23 (7A) :719-724
[5]   PROTEIN-KINASE-C REDUCES MG2+ BLOCK OF NMDA-RECEPTOR CHANNELS AS A MECHANISM OF MODULATION [J].
CHEN, L ;
HUANG, LYM .
NATURE, 1992, 356 (6369) :521-523
[6]   THYROTROPIN-RELEASING-HORMONE (TRH)-INDUCED FACILITATION OF SPINAL NEUROTRANSMISSION - A ROLE FOR NMDA RECEPTORS [J].
CHIZH, BA ;
HEADLEY, PM .
NEUROPHARMACOLOGY, 1994, 33 (01) :115-121
[7]   PROLONGED, NALOXONE-REVERSIBLE INHIBITION OF THE FLEXION REFLEX IN THE CAT [J].
CHUNG, JM ;
FANG, ZR ;
CARGILL, CL ;
WILLIS, WD .
PAIN, 1983, 15 (01) :35-53
[8]   MODULATION OF EXCITATORY AMINO-ACID RESPONSES BY TACHYKININS AND SELECTIVE TACHYKININ RECEPTOR AGONISTS IN THE RAT SPINAL-CORD [J].
CUMBERBATCH, MJ ;
CHIZH, BA ;
HEADLEY, PM .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (06) :1005-1012
[9]   EVIDENCE FOR INVOLVEMENT OF N-METHYLASPARTATE RECEPTORS IN WIND-UP OF CLASS-2 NEURONS IN THE DORSAL HORN OF THE RAT [J].
DAVIES, SN ;
LODGE, D .
BRAIN RESEARCH, 1987, 424 (02) :402-406
[10]   A CURE FOR WIND UP - NMDA RECEPTOR ANTAGONISTS AS POTENTIAL ANALGESICS [J].
DICKENSON, AH .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (08) :307-309