Role of functional polymorphism of matrix metalloproteinase-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter in oral submucous fibrosis and head and neck squamous cell carcinoma in an Indian population

被引：28

作者：

Chaudhary, Ajay Kumar ^{[1
,2
,4
]}

Pandya, Shruti ^{[2
,5
]}

Mehrotra, Ravi ^{[2
]}

Singh, Mangal ^{[3
]}

Singh, Mamta ^{[2
]}

机构：

[1] Univ Allahabad, Ctr Biotechnol, Allahabad 211002, Uttar Pradesh, India

[2] Moti Lal Nehru Med Coll, Dept Pathol, Allahabad, Uttar Pradesh, India

[3] Moti Lal Nehru Med Coll, Dept Otorhinolaryngol, Allahabad, Uttar Pradesh, India

[4] Tata Mem Hosp, Adv Ctr Treatment Res & Educ Canc ACTREC, Dept Translat Res, Navi Mumbai, India

[5] Tata Mem Hosp TMH, Dept Hematopathol, Bombay, Maharashtra, India

来源：

BIOMARKERS | 2011年 / 16卷 / 07期

关键词：

MMP; SNP; OSMF; HNSCC; genomics; LYMPH-NODE METASTASIS; SINGLE NUCLEOTIDE POLYMORPHISM; COLORECTAL-CANCER; GENE-EXPRESSION; BREAST-CANCER; LUNG-CANCER; MALIGNANT LESIONS; TISSUE INHIBITOR; TUMOR INVASION; GELATINASE-A;

D O I：

10.3109/1354750X.2011.609602

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The aim of this study was to explore the association of MMP-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter polymorphisms in oral submucous fibrosis (OSMF) and head and neck squamous cell carcinoma (HNSCC) cases. These SNP were genotyped by PCR-RFLP. Total of 1260 individuals were recruited, of which 412 OSMF, 422 HNSCC and 426 were controls. In HNSCC, MMP-2 (-1306 C/T) and MMP-9 (-1562C/T) polymorphism, T allele showed strong association (p < 0.00 and p < 0.01) as compared to healthy control respectively, but not in case of OSMF and showed significant association with increasing progression of clinico-pathological grading. We concluded that SNPs in the MMP-2 and -9 promoter region may be associated with susceptibility to HNSCC not in OSMF.

引用

页码：577 / 586

页数：10

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