Fecal Microbiota Transplant: Treatment Options for Clostridium difficile Infection in the Intensive Care Unit

被引：16

作者：

Han, Samuel ^{[1
]}

Shannahan, Sarah ^{[1
]}

Pellish, Randall ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Worcester, MA USA

来源：

JOURNAL OF INTENSIVE CARE MEDICINE | 2016年 / 31卷 / 09期

关键词：

fecal microbiota transplantation; refractory Clostridium difficile infection; recurrent Clostridium difficile colitis; fecal bacteriotherapy; BI; NAP1; 027; IN-VITRO ACTIVITY; REAL-TIME PCR; ENZYME-IMMUNOASSAY; TOXIN-B; PSEUDOMEMBRANOUS COLITIS; INTESTINAL MICROBIOTA; DOUBLE-BLIND; DIARRHEA; DISEASE; THERAPY;

D O I：

10.1177/0885066615594344

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Clostridium difficile infection (CDI) has steadily increased in incidence since the 1990s, with an associated increase in recurrence and severity, which has in turn lead to more intensive care unit (ICU) admissions. The development of recurrent CDI, in particular, has been associated with increasing patient morbidity and mortality as well as an immense financial burden on the health care system. Recently, fecal microbiota transplantation (FMT) has received much publicity as an effective means of treatment for recurrent CDI. The goal of this review is to provide evidence-based recommendations for the diagnosis and management of CDI, with a particular focus on FMT and its utilization in the ICU.

引用

页码：577 / 586

页数：10

共 139 条

[1]

Recurrent Clostridium difficile colitis:: Case series involving 18 patients treated with donor stool administered via a nasogastric tube [J].