Role-of lipopolysaccharide sialylation in serum resistance of serogroup B and C meningacoccal disease isolates

被引：47

作者：

Vogel, U ^{[1
]}

Claus, H ^{[1
]}

Heinze, G ^{[1
]}

Frosch, M ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Hyg & Mikrobiol, D-97080 Wurzburg, Germany

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 02期

关键词：

D O I：

10.1128/IAI.67.2.954-957.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

alpha-2,3-Sialyltransferase mutants of three genetically and phenotypically diverse Neisseria meningitidis strains were compared with regard to resistance to human serum and systemic spread in the infant rat. Lipopolysaccharide sialylation was found to be of minor importance for the resistance of serogroup B and C meningococcal disease isolates to complement attack.

引用

页码：954 / 957

页数：4

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