Serum thrombopoietin level in various hematological diseases

被引:57
作者
Usuki, K
Tahara, T
Iki, S
Endo, M
Osawa, M
Kitazume, K
Kato, T
Miyazaki, H
Urabe, A
机构
[1] KANTO TEISHIN HOSP, DIV HEMATOL, SHINAGAWA KU, TOKYO, JAPAN
[2] KIRIN BREWERY CO LTD, PHARMACEUT RES LAB, GUNMA, JAPAN
关键词
thrombopoietin; serum level; myelosuppressive state; leukemia; malignant lymphoma; idiopathic thrombocytopenic purpura; multiple myeloma; myelodysplastic syndrome; aplastic anemia; myeloproliferative disorders; liver cirrhosis;
D O I
10.1002/stem.140558
中图分类号
Q813 [细胞工程];
学科分类号
摘要
To investigate the pathophysiological role of thrombopoietin (TPO) in thrombopoiesis, we measured its serum levels in 15 healthy individuals, 84 patients with various hematological diseases and 2 patients with liver cirrhosis using an enzyme immunoassay procedure, The TPO level was 0.84 +/- 0.40 f mol/ml in normal individuals. TPO levels were considerably elevated in patients with myelosuppression after intensification chemotherapy of acute leukemia in complete remission (postchemotherapy group; n = 18; 18.46 +/- 9.70 f mol/ml), When the data of normal individuals and the postchemotherapy group were combined, TPO levels were inversely correlated with the platelet count in this combined group, We compared these data of normal individuals and the postchemotherapy group with various hematological disease states, In aplastic anemia (n = 13; 16.03 +/- 9.44 f mol/ml), acute lymphoblastic leukemia (n = 5; 10.36 +/- 5.57 f mol/ml), malignant lymphoma (n = 6; 2.79 +/- 2.27 fmol/ml), multiple myeloma (n = 3; 3.34 +/- 0.20 f mol/ml) and chronic lymphocytic leukemia (n = 2; 1.71 +/- 3.91 f mol/ml), the relationship of serum TPO levels and platelet counts was almost the same as in the combined group with normal individuals and the postchemotherapy group, However, the TPO levels were slightly higher in myeloproliferative disorders (II = 12; 1.99 +/- 1.47 f mol/ml) and lower in acute myelogenous leukemia (n = 8; 2.27 +/- 1.25 f mol/ml), hypoplastic leukemia (n = 3; 2.76 +/- 2.23 f mol/ml), myelodysplastic syndrome (n = 2; 0.42 +/- 0.60 f mol/ml), liver cirrhosis (n = 2; 1.50 +/- 0.92 fmol/ml) and idiopathic thrombocytopenic purpura (n = 12; 2.08 +/- 1.41 f mol/ml), when compared to the regression line for the combined group with normal individuals and postchemotherapy group, These findings suggest that TPO might play an important role in regulation of the platelet count in normal and pathological conditions.
引用
收藏
页码:558 / 565
页数:8
相关论文
共 40 条
[1]  
ATHENS JW, 1993, WINTROBES CLIN HEMAT, V2, P1999
[2]   IDENTIFICATION AND CLONING OF A MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR THAT IS A LIGAND FOR THE CYTOKINE RECEPTOR MPL [J].
BARTLEY, TD ;
BOGENBERGER, J ;
HUNT, P ;
LI, YS ;
LU, HS ;
MARTIN, F ;
CHANG, MS ;
SAMAL, B ;
NICHOL, JL ;
SWIFT, S ;
JOHNSON, MJ ;
HSU, RY ;
PARKER, VP ;
SUGGS, S ;
SKRINE, JD ;
MEREWETHER, LA ;
CLOGSTON, C ;
HSU, E ;
HOKOM, MM ;
HORNKOHL, A ;
CHOI, E ;
PANGELINAN, M ;
SUN, Y ;
MAR, V ;
MCNINCH, J ;
SIMONET, L ;
JACOBSEN, F ;
XIE, C ;
SHUTTER, J ;
CHUTE, H ;
BASU, R ;
SELANDER, L ;
TROLLINGER, D ;
SIEU, L ;
PADILLA, D ;
TRAIL, G ;
ELLIOTT, G ;
IZUMI, R ;
COVEY, T ;
CROUSE, J ;
GARCIA, A ;
XU, W ;
DELCASTILLO, J ;
BIRON, J ;
COLE, S ;
HU, MCT ;
PACIFICI, R ;
PONTING, I ;
SARIS, C ;
WEN, D .
CELL, 1994, 77 (07) :1117-1124
[3]   PROPOSALS FOR THE CLASSIFICATION OF THE MYELODYSPLASTIC SYNDROMES [J].
BENNETT, JM ;
CATOVSKY, D ;
DANIEL, MT ;
FLANDRIN, G ;
GALTON, DAG ;
GRALNICK, HR ;
SULTAN, C .
BRITISH JOURNAL OF HAEMATOLOGY, 1982, 51 (02) :189-199
[4]   CRITERIA FOR THE DIAGNOSIS OF ACUTE-LEUKEMIA OF MEGAKARYOCYTE LINEAGE (M7) - A REPORT OF THE FRENCH-AMERICAN-BRITISH COOPERATIVE GROUP [J].
BENNETT, JM ;
CATOVSKY, D ;
DANIEL, MT ;
FLANDRIN, G ;
GALTON, DAG ;
GRALNICK, HR ;
SULTAN, C .
ANNALS OF INTERNAL MEDICINE, 1985, 103 (03) :460-462
[5]   PROPOSAL FOR THE RECOGNITION OF MINIMALLY DIFFERENTIATED ACUTE MYELOID-LEUKEMIA (AML-MO) [J].
BENNETT, JM ;
CATOVSKY, D ;
DANIEL, MT ;
FLANDRIN, G ;
GALTON, DAG ;
GRALNICK, HR ;
SULTAN, C .
BRITISH JOURNAL OF HAEMATOLOGY, 1991, 78 (03) :325-329
[6]   PROPOSED REVISED CRITERIA FOR THE CLASSIFICATION OF ACUTE MYELOID-LEUKEMIA - A REPORT OF THE FRENCH-AMERICAN-BRITISH COOPERATIVE GROUP [J].
BENNETT, JM ;
CATOVSKY, D ;
DANIEL, MT ;
FLANDRIN, G ;
GALTON, DAG ;
GRALNICK, HR ;
SULTAN, C .
ANNALS OF INTERNAL MEDICINE, 1985, 103 (04) :620-625
[7]  
BERRIDGE MV, 1988, BLOOD, V72, P970
[8]  
BITHELL TC, 1993, WINTROBES CLIN HEMAT, V2, P1325
[9]   THROMBOPOIETIN (C-MPL LIGAND) ACTS SYNERGISTICALLY WITH ERYTHROPOIETIN, STEM-CELL FACTOR, AND INTERLEUKIN-11 TO ENHANCE MURINE MEGAKARYOCYTE COLONY GROWTH AND INCREASES MEGAKARYOCYTE PLOIDY IN-VITRO [J].
BROUDY, VC ;
LIN, NL ;
KAUSHANSKY, K .
BLOOD, 1995, 85 (07) :1719-1726
[10]   THE MPI RECEPTOR IS EXPRESSED IN THE MEGAKARYOCYTIC LINEAGE FROM LATE PROGENITORS TO PLATELETS [J].
DEBILI, N ;
WENDLING, F ;
COSMAN, D ;
TITEUX, M ;
FLORINDO, C ;
DUSANTERFOURT, I ;
SCHOOLEY, K ;
METHIA, N ;
CHARON, M ;
NADOR, R ;
BETTAIEB, A ;
VAINCHENKER, W .
BLOOD, 1995, 85 (02) :391-401