anti-1,2-diols via Ni-catalyzed reductive coupling of alkynes and α-oxyaldehydes

被引：57

作者：

Luanphaisarnnont, T ^{[1
]}

Ndubaku, CO ^{[1
]}

Jamison, TF ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 14期

关键词：

D O I：

10.1021/ol050881k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ni-catalyzed reductive coupling of aryl alkynes (1) and enantiornerically enriched alpha-oxyaldehydes (2) afford differentiated anti-1,2-diols (3) with high diastereoselectivity and regioselectivity, despite the fact that the methoxymethyl (MOM) and para-methoxybenzyl (PMB) protective groups typically favor syn-1,2-diol formation in carbonyl addition reactions of this family of aldehydes.

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页码：2937 / 2940

页数：4

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