The role of trivalent dimethylated arsenic in dimethylarsinic acid-promoted skin and lung tumorigenesis in mice: Tumor-promoting action through the induction of oxidative stress

被引：38

作者：

Mizoi, M

Takabayashi, F

Nakano, M

An, Y

Sagesaka, Y

Kato, K

Okada, S

Yamanaka, K

机构：

[1] Nihon Univ, Coll Pharm, Dept Environm Toxicol & Carcinogenesis, Funabashi, Chiba 2748555, Japan

[2] Univ Shizuoka, Coll Shizuoka, Shizuoka 4228021, Japan

[3] Natl Chiba Hosp, Chuo Ku, Chiba 2608606, Japan

[4] Ito En Ltd, Cent Res Inst, Shizuoka 4210516, Japan

[5] Univ Shizuoka, Shizuoka 4210103, Japan

来源：

TOXICOLOGY LETTERS | 2005年 / 158卷 / 02期

关键词：

dimethylarsinic acid; trivalent dimethylated arsenic; tumor promotion; 8-oxo-2 '-deoxyguanosine; oxidative stress;

D O I：

10.1016/j.toxlet.2005.03.009

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We investigated the relationship between lung- and skin-tumor promotion and oxidative stress caused by administration of dimethylarsinic acid (DMA(V)) in mice. The incidence of lung tumors induced by lung tumor initiator (4NQO) and DMA(V) were, as well as 8-oxo-2'-deoxyguanosine (8-oxodG), suppressed by cotreatment with (-)epigallocatechin gallate (EGCG). When mice were topically treated with trivalent dimethylated arsenic (DMA(Ill)), a further reductive metabolite of DMA(V), not only an increase in skin tumors but also an elevation of 8-oxodG in epidermis were observed. These results suggest that tumor promotion due to DMA(V) administration is mediated by DMA(III) through the induction of oxidative stress. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：87 / 94

页数：8

共 30 条

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