Large and stable transmembrane pores from guanosine-bile acid conjugates

被引：93

作者：

Ma, Ling ^{[1
]}

Melegari, Monica ^{[1
]}

Colombini, Marco ^{[2
]}

Davis, Jeffery T. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

[2] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 10期

关键词：

D O I：

10.1021/ja7110702

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report that a ditopic guanosine-lithocholic acid conjugate forms discrete channels in planar phospholipid membranes. These pores are large, with nanoSiemens conductance levels, and stable, with "open" times of seconds, distinguishing them from most synthetic channels, which typically conduct in the picosiemens range with millisecond lifetimes. We propose that these large pores are due to the formation of G4-quartet based superstructures within the membrane.

引用

页码：2938 / 2939

页数：2

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