Cytotoxic constituents of Psoralea corylifolia

被引：68

作者：

Mar, W

Je, KH

Seo, EK ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Nat Prod Chem Lab, Seoul 120750, South Korea

[2] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 03期

关键词：

Psoralea corylifolia; psoralidin; angelicin; psoralen; cytotoxicity;

D O I：

10.1007/BF02978259

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 mug/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.

引用

页码：211 / 213

页数：3

共 9 条

[1]

PSORALEN AN INHIBITOR IN SEEDS OF PSORALEA SUBACAULIS (LEGUMINOSAE) [J].