Cognitive neuroepigenetics: A role for epigenetic mechanisms in learning and memory

被引：94

作者：

Day, Jeremy J.

Sweatt, J. David ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Neurobiol, Birmingham, AL 35294 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 96卷 / 01期

关键词：

Learning; Memory; Epigenetics; DNA methylation; LONG-TERM-MEMORY; ACTIVE DNA DEMETHYLATION; CALMODULIN KINASE-II; ORIGIN ALLELIC EXPRESSION; PROTEIN-SYNTHESIS; FEAR MEMORY; HISTONE ACETYLATION; SYNAPTIC PLASTICITY; PREFRONTAL CORTEX; MOUSE-BRAIN;

D O I：

10.1016/j.nlm.2010.12.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Although long-lasting behavioral memories have long been thought to require equally persistent molecular changes, little is known about the biochemical underpinnings of memory storage and maintenance. Increasing evidence now suggests that long-term behavioral change may be associated with epigenetic regulation of transcription in the central nervous system. In this review, we present evidence that changes in DNA methylation contribute to memory formation and maintenance, consider how DNA methylation affects readout of memory-related genes, and discuss how these changes may be important in the large-scale context of memory circuits. Finally, we discuss potential challenges involved in examining epigenetic changes in the brain and highlight how epigenetic mechanisms may be relevant for other cognitive processes. (c) 2011 Elsevier Inc. All rights reserved.

引用

页码：2 / 12

页数：11

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[1] Endogenous BDNF is required for long-term memory formation in the rat parietal cortex [J].