Weight loss increases cardiovagal baroreflex function in obese young and older men

被引:38
作者
Alvarez, GE [1 ]
Davy, BM [1 ]
Ballard, TP [1 ]
Beske, SD [1 ]
Davy, KP [1 ]
机构
[1] Virginia Polytech Inst & State Univ, Dept Human Nutr Foods & Exercise, Human Integrat Physiol Lab, Blacksburg, VA 24061 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2005年 / 289卷 / 04期
关键词
aging; obesity; baroreflex;
D O I
10.1152/ajpendo.00487.2004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We tested the hypothesis that reductions in total body and abdominal visceral fat with energy restriction would be associated with increases in cardiovagal baroreflex sensitivity (BRS) in overweight/obese older men. To address this, overweight/obese (25 <= body mass index <= 35 kg/m(2)) young (OB-Y, n = 10, age = 32.9 +/- 2.3 yr) and older (OB-O, n = 6, age = 60+/- 2.7 yr) men underwent 3 mo of energy restriction at a level designed to reduce body weight by 5 - 10%. Cardiovagal BRS ( modified Oxford technique), body composition (dual-energy X-ray absorptiometry), and abdominal fat distribution ( computed tomography) were measured in the overweight/obese men before weight loss and after 4 wk of weight stability at their reduced weight and compared with a group of nonobese young men (NO-Y, n = 13, age = 21.1 +/- 1.0 yr). Before weight loss, cardiovagal BRS was similar to 35% and similar to 60% lower ( P < 0.05) in the OB-Y and OB-O compared with NO-Y. Body weight (- 7.8 +/- 1.1 vs. - 7.3 +/- 0.7 kg), total fat mass (- 4.1 +/- 1.0 vs. - 4.4 +/- 0.8 kg), and abdominal visceral fat ( - 27.6 +/- 6.9 vs. - 43.5 +/- 10.1 cm(2)) were reduced ( all P < 0.05) after weight loss, but the magnitude of reduction did not differ ( all P > 0.05) between OB-Y and OB-O, respectively. Cardiovagal BRS increased (11.5 /- 1.9 vs. 18.5 +/- 2.6 ms/mmHg and 6.7 +/- 1.2 vs. 12.8 +/- 4.2 ms/mmHg) after weight loss ( both P < 0.05) in OB-Y and OB-O, respectively. After weight loss, cardiovagal BRS in the obese/overweight young and older men was similar to 105% and similar to 73% ( P > 0.05) of NO-Y (17.5 +/- 2.2 ms/mmHg). Therefore, the results of this study indicate that weight loss increases the sensitivity of the cardiovagal baroreflex in overweight/obese young and older men.
引用
收藏
页码:E665 / E669
页数:5
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