Regulation of Rho GTPases by p120-catenin

被引：232

作者：

Anastasiadis, PZ ^{[1
]}

Reynolds, AB ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Canc Biol, Nashville, TN 37232 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(00)00258-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

引用

页码：604 / 610

页数：7

共 46 条

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