Par proteins: Partners in polarization

被引：103

作者：

Macara, AG ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Ctr Cell Signaling, Dept Microbiol, Charlottesville, VA 22908 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.cub.2004.01.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins can be localized either by inclusion or exclusion, and the Par polarity proteins illustrate both mechanisms. Cdc42 recruits Par-6 to a limited region of the plasma membrane. Par-6 recruits Par-3, which is actively removed from other regions by Par-1 and Par-5. Inclusion and exclusion together ensure efficient segregation of the polarity proteins.

引用

页码：R160 / R162

页数：3

共 20 条

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