Physiological functions of D-alanine carboxypeptidases in Escherichia coli

被引：121

作者：

Ghosh, Anindya S. ^{[1
]}

Chowdhury, Chiranjit ^{[1
]}

Nelson, David E. ^{[2
]}

机构：

[1] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, W Bengal, India

[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 07期

关键词：

D O I：

10.1016/j.tim.2008.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial cell shape is, in part, mediated by the peptidoglycan (murein) sacculus. Penicillin-binding proteins (PBPs) catalyze the final stages of murein biogenesis and are the targets of p-lactam antibiotics. Several low molecular mass PBPs including PBP4, PBP5, PBP6 and DacD seem to possess DD-carboxypeptidase (DD-CPase) activity, but these proteins are dispensable for survival in laboratory culture. The physiological functions of DD-CPases in vivo are unresolved and it is unclear why bacteria retain these seemingly non-essential and enzymatically redundant enzymes. However, PBP5 clearly contributes to maintenance of cell shape in some PBP mutant backgrounds. In this review, we focus on recent findings concerning the physiological functions of the DD-CPases in vivo, identify gaps in the current knowledge of these proteins and suggest some possible courses for future study that might help reconcile current models of bacterial cell morphology.

引用

页码：309 / 317

页数：9

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