The pathogenesis of the bone disease of multiple myeloma

被引：163

作者：

Edwards, Claire M. ^{[1
]}

Zhuang, Junling ^{[1
]}

Mundy, Gregory R. ^{[2
]}

机构：

[1] Vanderbilt Univ, Dept Canc Biol, Vanderbilt Ctr Bone Biol, Nashville, TN 37203 USA

[2] Vanderbilt Univ, Dept Med Clin Pharmacol, Vanderbilt Ctr Bone Biol, Nashville, TN USA

来源：

BONE | 2008年 / 42卷 / 06期

关键词：

multiple myeloma; osteoclast; osteoblast; RANKL; Dkk1;

D O I：

10.1016/j.bone.2008.01.027

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Multiple myeloma is a fatal hematologic malignancy associated with clonal expansion of malignant plasma cells within the bone marrow and the development of a destructive osteolytic bone disease. The principal cellular mechanisms involved in the development of myeloma bone disease are an increase in osteoclastic bone resorption, and a reduction in bone formation. Myeloma cells are found in close association with sites of active bone resorption, and the interactions between myeloma cells and other cells within the specialized bone marrow microenvironment are essential, both for tumor growth and the development of myeloma bone disease. This review discusses the many different factors which have been implicated in myeloma bone disease, including the evidence for their role in myeloma and subsequent therapeutic implications. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1007 / 1013

页数：7

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