A study on the compliance of a right coronary artery and its impact on wall shear stress

被引:56
作者
Zeng, Dehong [1 ]
Boutsianis, Evangelos [1 ]
Ammann, Marc [1 ]
Boomsma, Kevin [1 ]
Wildermuth, Simon [2 ]
Poulikakos, Dimos [1 ]
机构
[1] ETH, Dept Mech & Proc Engn, Lab Thermodynam Emerging Technol, CH-8092 Zurich, Switzerland
[2] Univ Zurich Hosp, Inst Diagnost Radiol, CH-8091 Zurich, Switzerland
来源
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2008年 / 130卷 / 04期
关键词
dynamic geometry; coronary arteries; Navier-Stokes equations; CFD model; moving grid; cardiac CT;
D O I
10.1115/1.2937744
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A computational model incorporating physiological motion and uniform transient wall deformation of a branchless right coronary artery (RCA) was developed to assess the influence of artery compliance on wall shear stress (WSS). Arterial geometry and deformation were derived from modern medical imaging techniques, whereas the blood flow was solved numerically employing a moving-grid approach using a well-validated in-house finite element code. The simulation results indicate that artery compliance affects the WSS in the RCA heterogeneously, with the distal region mostly experiencing these effects. Under physiological inflow conditions, coronary compliance contributed to phase changes in the WSS time history, without affecting the temporal gradient of the local WSS nor the bounds of the WSS magnitude. Compliance does not cause considerable changes to the topology of WSS vector patterns nor to the localization of WSS minima along the RCA. We conclude that compliance is not an important factor affecting local hemodynamics in the proximal region of the RCA while the influence of compliance in the distal region needs to be evaluated in conjunction with the outflow to the myocardium through the major branches of the RCA.
引用
收藏
页数:11
相关论文
共 43 条
[1]   FLOW PATTERNS AND SPATIAL-DISTRIBUTION OF ATHEROSCLEROTIC LESIONS IN HUMAN CORONARY-ARTERIES [J].
ASAKURA, T ;
KARINO, T .
CIRCULATION RESEARCH, 1990, 66 (04) :1045-1066
[2]   ANALYSIS OF CORONARY FLOW FIELDS IN THORACOTOMIZED DOGS [J].
ATABEK, HB ;
LING, SC ;
PATEL, DJ .
CIRCULATION RESEARCH, 1975, 37 (06) :752-761
[3]   Blood flow patterns in an anatomically realistic coronary vessel: Influence of three different reconstruction methods [J].
Berthier, B ;
Bouzerar, R ;
Legallais, C .
JOURNAL OF BIOMECHANICS, 2002, 35 (10) :1347-1356
[4]   Computational simulation of intracoronary flow based on real coronary geometry [J].
Boutsianis, E ;
Dave, H ;
Frauenfelder, T ;
Poulikakos, D ;
Wildermuth, S ;
Turina, M ;
Ventikos, Y ;
Zund, G .
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2004, 26 (02) :248-256
[5]  
CARO CG, 1971, CLIN SCI, V40, pP5
[6]   Coronary artery dynamics in vivo [J].
Ding, ZH ;
Zhu, H ;
Friedman, MH .
ANNALS OF BIOMEDICAL ENGINEERING, 2002, 30 (04) :419-429
[7]   Dynamics of human coronary arterial motion and its potential role in coronary atherogenesis [J].
Ding, ZH ;
Friedman, MH .
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2000, 122 (05) :488-492
[8]   Quantification of 3-D coronary arterial motion using clinical biplane cineangiograms [J].
Ding, ZH ;
Friedman, MH .
INTERNATIONAL JOURNAL OF CARDIAC IMAGING, 2000, 16 (05) :331-346
[9]  
Dorsaz PA, 2000, EUR HEART J, V21, P250
[10]   Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque [J].
Feldman, CL ;
Stone, PH .
CURRENT OPINION IN CARDIOLOGY, 2000, 15 (06) :430-440