A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily

被引：19

作者：

Cao, JX

Koop, BF

Upton, C

机构：

[1] UNIV VICTORIA,DEPT BIOCHEM & MICROBIOL,VICTORIA,BC V8W 2Y2,CANADA

[2] UNIV VICTORIA,DEPT BIOL CEH,VICTORIA,BC V8W 2Y2,CANADA

来源：

VIRUS RESEARCH | 1997年 / 48卷 / 01期

关键词：

prototypic poxvirus; vaccinia virus; phospholipase D;

D O I：

10.1016/S0168-1702(96)01422-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have identified a human gene encoding a protein with 48% amino acid identity to the vaccinia virus (VV) K4L gene product. Both contain motifs characteristic of the phospholipase D (PLD) protein superfamily. These proteins are also related to vaccinia virus p37, encoded by the F13L gene, which is required for envelopment and spread of the virus. The similarity to phospholipase D provides insight into the mechanisms and evolution of these processes. (C) 1997 Elsevier Science B.V.

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页码：11 / 18

页数：8

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