The channel of death

被引：37

作者：

Degterev, A ^{[1
]}

Boyce, M ^{[1
]}

Yuan, JY ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

JOURNAL OF CELL BIOLOGY | 2001年 / 155卷 / 05期

关键词：

D O I：

10.1083/jcb.200110147

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mitochondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors.

引用

页码：695 / 697

页数：3

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