A study of the effects of indometacin on liver mitochondria from rats, mice and humans

被引：30

作者：

Jacob, M

Bjarnason, I

Rafi, S

Wrigglesworth, J

Simpson, RJ

机构：

[1] Guys Kings & St Thomass Sch Med, Dept Endocrinol Diabet & Internal Med, London SE5 9PJ, England

[2] Christian Med Coll & Hosp, Dept Biochem, Vellore, Tamil Nadu, India

[3] Guys Kings & St Thomass Sch Med, Dept Clin Biochem, London SE5 9PJ, England

[4] Kings Coll London, Div Life Sci, London W8 7AH, England

来源：

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2001年 / 15卷 / 11期

关键词：

D O I：

10.1046/j.1365-2036.2001.01095.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: A part of the mechanism of the gastrointestinal toxicity exhibited by non-steroidal anti-inflammatory drugs is believed to involve the uncoupling of mitochondrial oxidative phosphorylation. Most previous uncoupling studies have used rat liver mitochondria. There is little information on the effects of the drugs on mitochondria from other species. Aim: To study the effect of indometacin on isolated liver mitochondria from rats, mice and humans. Methods: We studied the effects of indometacin on respiration and adenosine triphosphate synthesis by isolated liver mitochondria from rats, mice and humans.

引用

页码：1837 / 1842

页数：6

共 24 条

[1] POSSIBLE BASIS FOR THE ANTI-INFLAMMATORY ACTIVITY OF SALICYLATES AND OTHER NON-HORMONAL ANTI-RHEUMATIC DRUGS [J].

ADAMS, SS ;

COBB, R .

NATURE, 1958, 181 (4611) :773-774

[2]

Anand BS, 1999, AM J GASTROENTEROL, V94, P1818

[3]

BEUTLER E, 1975, RED CELL METABOLISM, P119

[4]

Brown G.C.N.D.G., 1999, MITOCHONDRIA CELL DE

[5]

BRUNE K, 1987, SCAND J RHEUMATOL, P135

[6]

GULLIKSON GW, 1977, GASTROENTEROLOGY, V73, P501

[7]

KAWAI K, 1985, RES COMMUN CHEM PATH, V48, P267

[8] Mitochondrial control of apoptosis [J].

Kroemer, G ;

Zamzami, N ;

Susin, SA .

IMMUNOLOGY TODAY, 1997, 18 (01) :44-51

[9] PROSTAGLANDIN-SYNTHASE-1 GENE DISRUPTION IN MICE REDUCES ARACHIDONIC ACID-INDUCED INFLAMMATION AND INDOMETHACIN-INDUCED GASTRIC-ULCERATION [J].

LANGENBACH, R ;

MORHAM, SG ;

TIANO, HF ;

LOFTIN, CD ;

GHANAYEM, BI ;

CHULADA, PC ;

MAHLER, JF ;

LEE, CA ;

GOULDING, EH ;

KLUCKMAN, KD ;

KIM, HS ;

SMITHIES, O .

CELL, 1995, 83 (03) :483-492

[10] NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS) ASSOCIATE WITH ZWITTERIONIC PHOSPHOLIPIDS - INSIGHT INTO THE MECHANISM AND REVERSAL OF NSAID-INDUCED GASTROINTESTINAL INJURY [J].

LICHTENBERGER, LM ;

WANG, ZM ;

ROMERO, JJ ;

ULLOA, C ;

PEREZ, JC ;

GIRAUD, MN ;

BARRETO, JC .

NATURE MEDICINE, 1995, 1 (02) :154-158

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