Emerging insights into the molecular and cellular basis of glioblastoma

被引：469

作者：

Dunn, Gavin P. ^{[1
,2
,3
]}

Rinne, Mikael L. ^{[1
,3
,4
]}

Wykosky, Jill ^{[5
]}

Genovese, Giannicola ^{[1
]}

Quayle, Steven N. ^{[1
]}

Dunn, Ian F. ^{[6
]}

Agarwalla, Pankaj K. ^{[1
,2
,3
]}

Chheda, Milan G. ^{[1
,3
,7
]}

Campos, Benito ^{[8
]}

Wang, Alan ^{[9
]}

Brennan, Cameron ^{[10
]}

Ligon, Keith L. ^{[11
]}

Furnari, Frank ^{[5
,12
]}

Cavenee, Webster K. ^{[5
]}

Depinho, Ronald A. ^{[9
]}

Chin, Lynda ^{[13
]}

Hahn, William C. ^{[1
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Mol & Cellular Oncol,Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurosurg, Boston, MA 02114 USA

[3] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

[4] Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02215 USA

[5] Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[6] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurosurg, Boston, MA 02115 USA

[7] Mem Sloan Kettering Canc Ctr, Brain Tumor Ctr, Dept Neurol, New York, NY 10065 USA

[8] Heidelberg Univ, Dept Neurosurg, Heidelberg, Germany

[9] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

[10] Mem Sloan Kettering Canc Ctr, Brain Tumor Ctr, Dept Neurosurg, New York, NY 10065 USA

[11] Dana Farber Canc Inst, Ctr Mol Oncol Pathol, Dept Med Oncol, Boston, MA 02215 USA

[12] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[13] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Genom Med, Houston, TX 77030 USA

来源：

GENES & DEVELOPMENT | 2012年 / 26卷 / 08期

关键词：

glioblastoma; invasion; angiogenesis; tumor-initiating cells; IDH1; glioma classification; GROWTH-FACTOR-RECEPTOR; ISOCITRATE DEHYDROGENASE 1; NEURAL STEM-CELLS; BEVACIZUMAB PLUS IRINOTECAN; INTEGRATED GENOMIC ANALYSIS; COPY-NUMBER ALTERATION; ACUTE MYELOID-LEUKEMIA; PRIMARY BRAIN-TUMORS; CODON; 132; MUTATION; PHASE-II TRIAL;

D O I：

10.1101/gad.187922.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma'' represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.

引用

页码：756 / 784

页数：29

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